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List of substances for condition Group: Arthritis

All Human Animal Risk/Association ReviewRows: 410

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Curcumin 📋✍⛔38707049Efficacy and Safety of Two Chondroprotective Supplements in Patients With Knee Osteoarthritis: A Randomized, Single-Blind, Pilot Study
Vitamin D3 📋✍⛔38306069Relationship between serum vitamin D levels and the prevalence of knee osteoarthritis: A retrospective study on 3424 subjects
Resveratrol 📋✍⛔38466008Resveratrol Attenuates Rheumatoid Arthritis Induce Neutrophil Extracellular Traps via TLR-4 Mediated Inflammation in C57BL/6 Mice
Quercetin 📋✍⛔38372204Quercetin as a promising intervention for rat osteoarthritis by decreasing M1-polarized macrophages via blocking the TRPV1-mediated P2X7/NLRP3 signaling pathway
Frankincense 📋✍⛔38707049Efficacy and Safety of Two Chondroprotective Supplements in Patients With Knee Osteoarthritis: A Randomized, Single-Blind, Pilot Study
Glucosamine 📋✍⛔38732122Glucosamine and Silibinin Alter Cartilage Homeostasis through Glycosylation and Cellular Stresses in Human Chondrocyte Cells
Berberine 📋✍⛔38305937Natural compound library screening to identify berberine as a treatment for rheumatoid arthritis
Omega-3 Fatty Acids 📋✍⛔38248642The Role of Marine n-3 Polyunsaturated Fatty Acids in Inflammatory-Based Disease: The Case of Rheumatoid Arthritis
Chondroitin 📋✍⛔38707049Efficacy and Safety of Two Chondroprotective Supplements in Patients With Knee Osteoarthritis: A Randomized, Single-Blind, Pilot Study
Ginsenosides 📋✍⛔37883815Ginsenoside compound K exerts anti-inflammatory effects through transcriptional activation and transcriptional inhibition of glucocorticoid receptor in rheumatoid arthritis fibroblast-like synoviocytes
EGCG 📋✍⛔38259454J-shaped association of dietary catechins intake with the prevalence of osteoarthritis and moderating effect of physical activity: an American population-based cohort study
Melatonin 📋✍⛔38348943Melatonin is a potential novel analgesic agent for osteoarthritis: Evidence from cohort studies in humans and preclinical research in rats
Metformin 📋✍⛔37964313Effects of metformin therapy on HMGB1 levels in rheumatoid arthritis patients
Medicinal Plants 📋 38676473Nature's Pharmacy: Herbal Interventions in Rheumatoid Arthritis Treatment: A Comprehensive Review
Ginger 📋✍⛔38474869Zingiber Officinale Roscoe: The Antiarthritic Potential of a Popular Spice-Preclinical and Clinical Evidence
Cannabidiol 📋✍⛔37332213The Mechanism of Cannabichromene and Cannabidiol Alone Versus in Combination in the Alleviation of Arthritis-Related Inflammation
Hyaluronic Acid 📋✍⛔38707049Efficacy and Safety of Two Chondroprotective Supplements in Patients With Knee Osteoarthritis: A Randomized, Single-Blind, Pilot Study
Turmeric 📋✍⛔38180010Open, Observational, Single-Arm, Multicenter Study Assessing the Effectiveness of a Dietary Supplement Containing Hydrolyzed Collagen, Chondroitin Sulfate, and Glucosamine for Osteoarthritis Pain Reduction
Icariin 📋✍ 38636375Icariin inhibits chondrocyte ferroptosis and alleviates osteoarthritis by enhancing the SLC7A11/GPX4 signaling
Avocado 📋✍⛔37936023Comprehensive phytochemical characterization of Persea americana Mill. fruit via UPLC/HR-ESI-MS/MS and anti-arthritic evaluation using adjuvant-induced arthritis model
Nigella Sativa 📋✍⛔38650731The efficacy and safety of Nigella sativa in the management of osteoarthritis: A systematic review
Andrographolide 📋 38462021Elucidation of the key therapeutic targets and potential mechanisms of Andrographolide multi-targets against osteoarthritis via network pharmacological analysis and experimental validation
Collagen 📋✍ 38180010Open, Observational, Single-Arm, Multicenter Study Assessing the Effectiveness of a Dietary Supplement Containing Hydrolyzed Collagen, Chondroitin Sulfate, and Glucosamine for Osteoarthritis Pain Reduction
Vitamin C 📋✍⛔38599880Vitamin C alleviates rheumatoid arthritis by modulating gut microbiota balance
Baicalin 📋✍⛔38377551Baicalin Maintains Articular Cartilage Homeostasis and Alleviates Osteoarthritis by Activating FOXO1
Boswellic Acid 📋✍⛔36869332Evaluation of the effectiveness of topical oily solution containing frankincense extract in the treatment of knee osteoarthritis: a randomized, double-blind, placebo-controlled clinical trial
Fish Oil 📋✍⛔35099432Efficacy of Flaxseed and Fish Oils on Adults with Rheumatoid Arthritis
Hesperidin 📋✍⛔35657316Therapeutic role of hesperidin in collagen-induced rheumatoid arthritis through antiglycation and antioxidant activities
Micronutrients 📋 ⛔38258782A Systemic Review on Nutraceutical Supplements used in the Management of Osteoarthritis
Selenium 📋✍⛔38473759Selenium Lessens Osteoarthritis by Protecting Articular Chondrocytes from Oxidative Damage through Nrf2 and NF-κB Pathways
Soy 📋✍⛔35733624A Randomized Controlled Trial of Thai Medicinal Plant-4 Cream versus Diclofenac Gel in the Management of Symptomatic Osteoarthritis of the Knee
Angelica 📋✍⛔37632225Angelica sinensis polysaccharide improves mitochondrial metabolism of osteoarthritis chondrocytes through PPARγ/SOD2/ROS pathways
Astaxanthin 📋✍⛔38555717Astaxanthin reduces inflammation and promotes a chondrogenic phenotype by upregulating SIRT1 in osteoarthritis
Mangiferin 📋 ⛔38037139Extensive preclinical evaluation of combined mangiferin and glycyrrhizic acid for restricting synovial neovascularization in rheumatoid arthritis
Mangosteen 📋✍⛔36634312Hypouricemic Actions of the Pericarp of Mangosteen in Vitro and in Vivo
Naringenin 📋✍⛔37953787Naringenin attenuates inflammation and apoptosis of osteoarthritic chondrocytes via the TLR4/TRAF6/NF-κB pathway
Tanshinone 📋 38253247Tanshinone IIA attenuates osteoarthritis via inhibiting aberrant angiogenesis in subchondral bone
Vitamin E 📋✍⛔36986484The Role of Tocotrienol in Arthritis Management-A Scoping Review of Literature
Astragalosides 📋✍⛔37855351Astragaloside IV Protects Against IL-1β-Induced Chondrocyte Damage via Activating Autophagy
Astragalus Root 📋✍⛔38318502Systematic Pharmacology and Experimental Validation to Reveal the Alleviation of Astragalus membranaceus Regulating Ferroptosis in Osteoarthritis
Bee Venom 📋✍⛔38414737Melittin promotes dexamethasone in the treatment of adjuvant rheumatoid arthritis in rats
Cinnamon 📋✍⛔36160710Integrated Experimental Approach, Phytochemistry, and Network Pharmacology to Explore the Potential Mechanisms of Cinnamomi Ramulus for Rheumatoid Arthritis
Emodin 📋 ⛔38570055Protective effects of emodin on subchondral bone and articular cartilage in osteoporotic osteoarthritis rats: A preclinical study
Geniposide 📋 38185885A new look at angiogenesis inhibition of geniposide in experimental arthritis by blocking angiopoietin-2 exocytosis
Ginseng 📋✍⛔37664679Protective effects of ginseng and ginsenosides in the development of osteoarthritis (Review)
Magnesium 📋✍⛔38178208Systemic and local antiinflammatory effect of magnesium chloride in experimental arthritis
Pine Bark 📋✍⛔38381030Periostial and cartilage morphology in knee osteoarthritis: beneficial effects of supplementation with Pycnogenol® + Centellicum®
Apigenin 📋✍⛔38626647Targeting TNF-α-induced expression of TTR and RAGE in rheumatoid arthritis: Apigenin's mediated therapeutic approach
Ashwagandha 📋✍⛔34712426Anti-arthritic activity of Ricinus communis L. and Withania somnifera L. extracts in adjuvant-induced arthritic rats via modulating inflammatory mediators and subsiding oxidative stress
Crocin 📋✍⛔37031388The Combined Effect of Curcumin and Crocin on the Reduction of Inflammatory Responses in Arthritic Rats
Eucommia 📋✍⛔37123081Iridoid from Eucommia ulmoides Oliv. Exerts Antiarthritis Effects by Inhibiting the JAK2/STAT3 Signaling Pathway In Vivo and In Vitro
Flavonoids 📋 ⛔38201942Osteoarthritis in the Elderly Population: Preclinical Evidence of Nutrigenomic Activities of Flavonoids
Food 📋 38295091Causal relationship between diet and knee osteoarthritis: A Mendelian randomization analysis
Grape Seed extract 📋✍⛔36589610Grape seed proanthocyanidin extract induces apoptotic and autophagic cell death in rheumatoid arthritis fibroblast-like synoviocytes
Kaempferol 📋✍⛔37311931Kaempferol Attenuates Gouty Arthritis by Regulating the Balance of Th17/Treg Cells and Secretion of IL-17
Oleuropein 📋 37543863Oleuropein as An Effective Suppressor of Inflammation and MicroRNA-146a Expression in Patients with Rheumatoid Arthritis
Pomegranate 📋 ⛔35079584Systematic review of the effects of pomegranate ( Punica granatum) on osteoarthritis
Puerarin 📋✍⛔37548663Study on the mechanism of puerarin against osteoarthritis from ferroptosis based on network pharmacology and bioinformatics
Salidroside 📋 38409832Salidroside Protects Chondrocytes against IL-1β-Induced Injury and Alleviates Osteoarthritis Progression by Activating the Nrf2 Pathway
Vitamin K 📋✍⛔36184230Tailoring gut microbiota with a combination of Vitamin K and probiotics as a possible adjuvant in the treatment of rheumatic arthritis: a systematic review
Baicalein 📋✍⛔38525128Baicalein inhibits IL-1β-induced extracellular matrix degradation with decreased MCP-1 expression in primary rat chondrocytes
Bee Propolis 📋✍⛔37834215Ethanolic Extract of Propolis Modulates Autophagy-Related microRNAs in Osteoarthritic Chondrocytes
Bromelain 📋✍⛔35881306Combination of Enzymes and Rutin to Manage Osteoarthritis Symptoms: Lessons from a Narrative Review of the Literature
Cherry 📋 ⛔37679816Efficacy and safety of tart cherry supplementary citrate mixture on gout patients: a prospective, randomized, controlled study
Coffee 📋✍⛔38672942Dietary Factors and Risk of Gout: A Two-Sample Mendelian Randomization Study
Galangin 📋 36367487Galangin ameliorates osteoarthritis progression by attenuating extracellular matrix degradation in chondrocytes via the activation of PRELP expression
Ginkgolides 📋 38346525Ginkgolide C inhibits ROS-mediated activation of NLRP3 inflammasome in chondrocytes to ameliorate osteoarthritis
Goji Berry 📋✍⛔37439115Tissue lipidomics, network pharmacology, and molecular docking to explore the therapeutic mechanism of anthocyanins from Lycium ruthenicum Murr. against gouty arthritis
MSM 📋✍⛔30316071Methylsulfonylmethane and mobilee prevent negative effect of IL-1β in human chondrocyte cultures via NF-κB signaling pathway
Peony 📋 ⛔38649260Total glucosides of white paeony capsule alleviate articular cartilage degeneration and aberrant subchondral bone remodeling in knee osteoarthritis
Polyphenols 📋 37033930Efficacy and safety of dietary polyphenols in rheumatoid arthritis: A systematic review and meta-analysis of 47 randomized controlled trials
Procyanidins 📋 ⛔36274486Procyanidin B2 ameliorates the progression of osteoarthritis: An in vitro and in vivo study
Punicalagin 📋✍⛔34171516Punicalagin attenuates osteoarthritis progression via regulating Foxo1/Prg4/HIF3α axis
Wogonin 📋✍⛔38552763Wogonin inhibits the migration and invasion of fibroblast-like synoviocytes by targeting PI3K/AKT/NF-κB pathway in rheumatoid arthritis
Andrographis 📋✍⛔37354697Identification of Andrographolide as a novel FABP4 inhibitor for osteoarthritis treatment
Cardamonin 📋 38520666Cardamonin inhibits osteogenic differentiation by downregulating Wnt/beta-catenin signaling and alleviates subchondral osteosclerosis in osteoarthritic mice
Chrysanthemum 📋✍⛔38144783Identification of key phenolic compounds for alleviating gouty inflammation in edible chrysanthemums based on spectrum-effect relationship analyses
Chrysin 📋✍⛔37111711Chrysin Is Immunomodulatory and Anti-Inflammatory against Complete Freund's Adjuvant-Induced Arthritis in a Pre-Clinical Rodent Model
Cinnamaldehyde 📋 33118610The protective impact of Trans-Cinnamaldehyde (TCA) against the IL-1b induced inflammation in in vitro osteoarthritis model by regulating PI3K/AKT pathways
Docosahexaenoic Acid 📋✍⛔37450265DHA attenuates cartilage degeneration by mediating apoptosis and autophagy in human chondrocytes and rat models of osteoarthritis
Fucoidan 📋✍⛔36430716In Vitro Study of the Therapeutic Potential of Brown Crude Fucoidans in Osteoarthritis Treatment
Genistein 📋✍⛔37755294Genistein Suppresses IL-6 and MMP-13 to Attenuate Osteoarthritis in Obese Diabetic Mice
Glycyrrhizic Acid 📋✍⛔38037139Extensive preclinical evaluation of combined mangiferin and glycyrrhizic acid for restricting synovial neovascularization in rheumatoid arthritis
Krill Oil 📋✍⛔37888448Anti-Osteoarthritic Effects of Antarctic Krill Oil in Primary Chondrocytes and a Surgical Rat Model of Knee Osteoarthritis
Ollive Leaf extract 📋✍⛔35003721Potential benefit of olive leaf extract in cervical spondylotic myelopathy model
Paeoniflorin 📋 38726183Paeoniflorin inhibits the inflammation of rheumatoid arthritis fibroblast-like synoviocytes by downregulating hsa_circ_009012
Phytochemicals 📋 38360724Natural products in osteoarthritis treatment: bridging basic research to clinical applications
Probiotics 📋✍⛔36217542Safety and efficacy of probiotic supplementation in 8 types of inflammatory arthritis: A systematic review and meta-analysis of 34 randomized controlled trials
Pterostilbene 📋✍⛔38624135Pterostilbene Protects against Osteoarthritis through NLRP3 Inflammasome Inactivation and Improves Gut Microbiota as Evidenced by In Vivo and In Vitro Studies
Reishi Mushrooms 📋✍⛔37586160Ganoderma lucidum polysaccharide peptide (GLPP) attenuates rheumatic arthritis in rats through inactivating NF-κB and MAPK signaling pathways
Rutin 📋✍⛔35881306Combination of Enzymes and Rutin to Manage Osteoarthritis Symptoms: Lessons from a Narrative Review of the Literature
Senolytics 📋 38494091Senolytic therapeutics: An emerging treatment modality for osteoarthritis
Sulforaphane 📋✍⛔34184072Sulforaphane protects against oxidative stress‑induced apoptosis via activating SIRT1 in mouse osteoarthritis
Tea 📋 38672942Dietary Factors and Risk of Gout: A Two-Sample Mendelian Randomization Study
Allicin 📋✍⛔34026055Allicin regulates Treg/Th17 balance in mice with collagen-induced arthritis by increasing the expression of MEKK2 protein
Beta-Cryptoxanthin 📋 37378145Diet as a Risk Factor for Rheumatoid Arthritis
Calycosin 📋 38254101Calycosin ameliorates osteoarthritis by regulating the imbalance between chondrocyte synthesis and catabolism
Carnosic Acid 📋 36296709Combination Therapy of Carnosic Acid and Methotrexate Effectively Suppressed the Inflammatory Markers and Oxidative Stress in Experimental Arthritis
CoQ10 📋✍⛔34505525Treatment with coenzyme Q10, omega-3-polyunsaturated fatty acids and their combination improved bioenergetics and levels of coenzyme Q9 and Q10 in skeletal muscle mitochondria in experimental model of arthritis
Ellagic Acid 📋✍⛔37839112Bixa orellana ethyl acetate fraction and its isolated compound ellagic acid attenuate the progression of MIA-induced osteoarthritis in rat knees
Garlic 📋✍⛔36013310Bioactive Compounds in Garlic ( Allium sativum) and Black Garlic as Antigout Agents, Using Computer Simulation
Ginger extract 📋✍⛔36837393Hemp Seed Oil in Association with β-Caryophyllene, Myrcene and Ginger Extract as a Nutraceutical Integration in Knee Osteoarthritis: A Double-Blind Prospective Case-Control Study
Gotu Kola 📋✍⛔38381030Periostial and cartilage morphology in knee osteoarthritis: beneficial effects of supplementation with Pycnogenol® + Centellicum®
Hydroxytyrosol 📋 36982904NOTCH1: A Novel Player in the Molecular Crosstalk Underlying Articular Chondrocyte Protection by Oleuropein and Hydroxytyrosol
L-Carnitine 📋✍⛔38389158Effect of l-Carnitine Supplementation on Osteoarthritis: A Systematic Review
Licochalcones 📋 32965793Activating Nrf2 signalling alleviates osteoarthritis development by inhibiting inflammasome activation
Luteolin 📋✍⛔37390879Therapeutic effects of Siegesbeckia orientalis L. and its active compound luteolin in rheumatoid arthritis: network pharmacology, molecular docking and experimental validation
Lycopene 📋✍⛔33860572Activation of autophagy contributes to the protective effects of lycopene against oxidative stress-induced apoptosis in rat chondrocytes
N-Acetyl Cysteine 📋✍⛔35133468Effects of N-acetylcysteine supplementation on disease activity, oxidative stress, and inflammatory and metabolic parameters in rheumatoid arthritis patients: a randomized double-blind placebo-controlled trial
Naringin 📋✍⛔34054546Therapeutic Effects of Naringin in Rheumatoid Arthritis: Network Pharmacology and Experimental Validation
Olive Polyphenols 📋 33922438Dietary Oleocanthal Supplementation Prevents Inflammation and Oxidative Stress in Collagen-Induced Arthritis in Mice
Pomegranate Peel extract 📋✍⛔32794641Antiosteoarthritic effect of Punica granatum L. peel extract on collagenase induced osteoarthritis rat by modulation of COL-2, MMP-3, and COX-2 expression
Theaflavins 📋✍ 36990009Mechanisms of theaflavins against gout and strategies for improving the bioavailability
Anethole 📋 37987213Anethole mitigates H2 O2 -induced inflammation in HIG-82 synoviocytes by suppressing the aquaporin 1 expression and activating the protein kinase A pathway
Cat's Claw 📋✍⛔26088322Effect of Uncaria tomentosa extract on purinergic enzyme activities in lymphocytes of rats submitted to experimental adjuvant arthritis model
Dandelion 📋✍⛔30851708Taraxasterol suppresses inflammation in IL-1β-induced rheumatoid arthritis fibroblast-like synoviocytes and rheumatoid arthritis progression in mice
Dihydromyricetin 📋✍⛔32596704DMY protects the knee joints of rats with collagen-induced arthritis by inhibition of NF-κB signaling and osteoclastic bone resorption
Dioscin 📋 37055831Dioscin alleviates the progression of osteoarthritis: an in vitro and in vivo study
Essential Oils 📋 ⛔36990808The Effects of Self-Aromatherapy Massage on Pain and Sleep Quality in Patients with Rheumatoid Arthritis: A Randomized Controlled Trial
Eugenol 📋 35880357Eugenol protects chondrocytes and articular cartilage by downregulating JAK3/STAT4 signaling pathway
Fish Collagen 📋✍⛔38132929Low-Molecular-Weight Fish Collagen Peptide (Valine-Glycine-Proline-Hydroxyproline-Glycine-Proline-Alanine-Glycine) Prevents Osteoarthritis Symptoms in Chondrocytes and Monoiodoacetate-Injected Rats
Gallic Acid 📋 ⛔36840490Gallic acid regulates immune response in a mouse model of rheumatoid arthritis
Haritaki 📋✍⛔36969583Simultaneous quantitative analysis and in vitro anti-arthritic effects of five polyphenols from Terminalia chebula
Indian Gooseberry 📋 ⛔35449811Exploring the Mechanism through which Phyllanthus emblica L. Extract Exerts Protective Effects against Acute Gouty Arthritis: A Network Pharmacology Study and Experimental Validation
Kacip Fatimah 📋✍⛔32256360Anti-hyperuricemic and Anti-inflammatory Effects of Marantodes pumilum as Potential Treatment for Gout
Knotweed 📋✍⛔37016525The possibility of Polygonum cuspidatum Against Osteoarthritis Based on Network Pharmacology and Molecular Docking
L-Glutamine 📋✍⛔35831464Glutamine exerts a protective effect on osteoarthritis development by inhibiting the Jun N-terminal kinase and nuclear factor kappa-B signaling pathways
Licorice Root 📋✍⛔38092318Exploring the efficacy and mechanism of Glycyrrhizae Radix et Rhizoma in improving collagen-induced arthritis in mice
Nimbolide 📋 36437579Nimbolide attenuates complete Freund's adjuvant induced arthritis through expression regulation of toll-like receptors signaling pathway
Nobiletin 📋✍ 31978425Nobiletin suppresses IL-21/IL-21 receptor-mediated inflammatory response in MH7A fibroblast-like synoviocytes (FLS): An implication in rheumatoid arthritis
Polydatin 📋✍ 38606875Polydatin protects against articular cartilage degeneration by regulating autophagy mediated by the AMPK/mTOR signaling pathway
Schisandra 📋✍⛔37337779Schisandra extract ameliorates arthritis pathogenesis by suppressing the NF-κB and MAPK signalling pathways
Schisandrins 📋 38422325Schisandrin B ameliorates adjuvant-induced arthritis in rats via modulation of inflammatory mediators, oxidative stress, and HIF-1α/VEGF pathway
Shogaol 📋 366101246-Shogaol inhibits the proliferation, apoptosis, and migration of rheumatoid arthritis fibroblast-like synoviocytes via the PI3K/AKT/NF-κB pathway
Silibinin 📋✍ 38732122Glucosamine and Silibinin Alter Cartilage Homeostasis through Glycosylation and Cellular Stresses in Human Chondrocyte Cells
Skullcap 📋✍⛔38396803Network Pharmacology and Experimental Verifications to Discover Scutellaria baicalensis Georgi's Effects on Joint Inflammation, Destruction, and Pain in Osteoarthritis
Stigmasterol 📋 38064612Stigmasterol Depresses the Proliferation and Facilitates the Apoptosis of Fibroblast-Like Synoviocytes via the PI3K/AKT Signaling Pathway in Collagen-Induced Arthritis Rats
Acacetin 📋 33195691Acacetin Suppresses IL-1 β-Induced Expression of Matrix Metalloproteinases in Chondrocytes and Protects against Osteoarthritis in a Mouse Model by Inhibiting NF- κ B Signaling Pathways
Arctigenin 📋 32090454Arctigenin prevents the progression of osteoarthritis by targeting PI3K/Akt/NF-κB axis: In vitro and in vivo studies
Artemisinin 📋 37758057Piezo1 activation accelerates osteoarthritis progression and the targeted therapy effect of artemisinin
Asiatic Acid 📋 38477392Asiatic acid inhibits rheumatoid arthritis fibroblast-like synoviocyte growth through the Nrf2/HO-1/NF-κB signaling pathway
Blueberry 📋✍⛔31120380Anti-Inflammatory Action of Blueberry Polyphenols in HIG-82 Rabbit Synoviocytes
Capsaicin 📋✍⛔34006826TRPV1 alleviates osteoarthritis by inhibiting M1 macrophage polarization via Ca 2+/CaMKII/Nrf2 signaling pathway
Carvacrol 📋✍⛔35496367Carvacrol Alleviates Hyperuricemia-Induced Oxidative Stress and Inflammation by Modulating the NLRP3/NF-κB Pathwayt
Catalpol 📋 36598130Catalpol protects mouse ATDC5 chondrocytes against interleukin-1β-induced catabolism
Catechins 📋 38259454J-shaped association of dietary catechins intake with the prevalence of osteoarthritis and moderating effect of physical activity: an American population-based cohort study
Costus 📋✍⛔36451529Saussurea involucrata oral liquid regulates gut microbiota and serum metabolism during alleviation of collagen-induced arthritis in rats
Dihydroquercetin 📋 37399606Pharmacological activation of the Nrf2 pathway by Taxifolin remodels articular cartilage microenvironment for the therapy of Osteoarthritis
Diosmin 📋✍⛔36139795Diosmin and Trolox Have Anti-Arthritic, Anti-Inflammatory and Antioxidant Potencies in Complete Freund's Adjuvant-Induced Arthritic Male Wistar Rats: Roles of NF-κB, iNOS, Nrf2 and MMPs
Echinacoside 📋 38506417Anti-inflammatory effect of echinacoside in collagen-induced arthritis via Nrf2/Drp1 pathway
Escin 📋✍⛔30967782Network Pharmacology Based Research on the Combination Mechanism Between Escin and Low Dose Glucocorticoids in Anti-rheumatoid Arthritis
Eucalyptol 📋 38649658Molecular insights of Eucalyptol (1,8-Cineole) as an anti-arthritic agent: in vivo and in silico analysis of IL-17, IL-10, NF-κB, 5-LOX and COX-2
Evening Primrose Oil 📋✍⛔28346333Clinical Benefits of n-3 PUFA and ɤ-Linolenic Acid in Patients with Rheumatoid Arthritis
Folate 📋✍⛔37049476Associations of Homocysteine, Folate, and Vitamin B12 with Osteoarthritis: A Mendelian Randomization Study
Ginger Essential Oil 📋✍ 31144450Effects of aromatherapy massage on pain, functional state, and quality of life in an elderly individual with knee osteoarthritis
Ginkgo Biloba 📋✍⛔35281931Bilobalide Exerts Anti-Inflammatory Effects on Chondrocytes Through the AMPK/SIRT1/mTOR Pathway to Attenuate ACLT-Induced Post-Traumatic Osteoarthritis in Rats
Glycine 📋✍⛔35866033Effect of Different Collagen on Anterior Cruciate Ligament Transection and Medial Meniscectomy-Induced Osteoarthritis Male Rats
Glycyrrhetinic Acid 📋 38092318Exploring the efficacy and mechanism of Glycyrrhizae Radix et Rhizoma in improving collagen-induced arthritis in mice
Grape 📋 ⛔36878329Muscadine Grape (Vitis rotundifolia) and Wine Polyphenols Alleviated Arthritis and Restored the Gut Microbial Composition in Mice
Green Tea 📋✍⛔35145506Effects of β-Carotin and Green Tea Powder Diets on Alleviating the Symptoms of Gouty Arthritis and Improving Gut Microbiota in C57BL/6 Mice
Green Tea Polyphenols 📋✍⛔28038881Green Tea (Camellia Sinensis) for Patients With Knee Osteoarthritis: A Randomized Open-Label Active-Controlled Clinical Trial
Isoliquiritigenin 📋 38092318Exploring the efficacy and mechanism of Glycyrrhizae Radix et Rhizoma in improving collagen-induced arthritis in mice
Mulberry 📋 ⛔38309391Modulation of gut microbiota by crude mulberry polysaccharide attenuates knee osteoarthritis progression in rats
PUFA 📋 35526074Impact of type and dose of oral polyunsaturated fatty acid supplementation on disease activity in inflammatory rheumatic diseases: a systematic literature review and meta-analysis
Red Sage 📋✍⛔36147634Radix Salvia miltiorrhiza for Ankylosing Spondylitis: Determining Potential Inflammatory Molecular Targets and Mechanism Using Network Pharmacology
Rosehip 📋✍⛔34348637Anti-inflammatory and Analgesic Effects of Rosehip in Inflammatory Musculoskeletal Disorders and Its Active Molecules
Saffron 📋✍⛔37836391Crocus sativus L. Extract (Saffron) Effectively Reduces Arthritic and Inflammatory Parameters in Monotherapy and in Combination with Methotrexate in Adjuvant Arthritis
Scutellarin 📋 36271561Scutellarin ameliorates osteoarthritis by protecting chondrocytes and subchondral bone microstructure by inactivating NF-κB/MAPK signal transduction
Silymarin 📋✍⛔33610183Silymarin modulates catabolic cytokine expression through Sirt1 and SOX9 in human articular chondrocytes
Spermidine 📋 38367900Spermidine ameliorates osteoarthritis via altering macrophage polarization
Strawberry 📋✍⛔38003966Amelioration of Rheumatoid Arthritis by Fragaria nubicola (Wild Strawberry) via Attenuation of Inflammatory Mediators in Sprague Dawley Rats
Tamarind 📋 ⛔37351019Efficacy of a proprietary combination of Tamarindus indica seeds and Curcuma longa rhizome extracts in osteoarthritis: a clinical investigation
Tangeretin 📋 35104760Tangeretin suppresses osteoarthritis progression via the Nrf2/NF-κB and MAPK/NF-κB signaling pathways
Thymoquinone 📋 ⛔32793594In vitro Evaluation of the Anti-inflammatory Effects of Thymoquinone in Osteoarthritis and in silico Analysis of Inter-Related Pathways in Age-Related Degenerative Diseases
TUDCA 📋✍⛔33562298Molecular and Cellular Effects of Chemical Chaperone-TUDCA on ER-Stressed NHAC-kn Human Articular Chondrocytes Cultured in Normoxic and Hypoxic Conditions
Urolithins 📋 38465899Urolithin B reduces cartilage degeneration and alleviates osteoarthritis by inhibiting inflammation
Vitamin B12 📋✍⛔38401303Vitamin B12 inhibits peptidylarginine deiminases and ameliorates rheumatoid arthritis in CAIA mice
Walnut 📋 ⛔35929358Evaluating the anti-arthritic potential of walnut (Juglans regia L.) in FCA induced Sprague Dawley rats
Zinc 📋✍⛔37163819L-carnitine and Zinc supplementation impedes intestinal damage in methotrexate-treated adjuvant-induced arthritis rats: Reinstating enterocyte proliferation and trace elements
Aloe Vera 📋✍⛔35069052Preliminary Phytochemical Analysis: In-Vitro Comparative Evaluation of Anti-arthritic and Anti-inflammatory Potential of Some Traditionally Used Medicinal Plants
Antioxidants 📋 ⛔37185721Rheumatoid Arthritis and Reactive Oxygen Species: A Review
Apple Polyphenols 📋 ⛔35580540Apple polyphenols exhibits chondroprotective changes of synovium and prevents knee osteoarthritis
Argan Oil 📋✍⛔28699499Effectiveness of Argan Oil Consumption on Knee Osteoarthritis Symptoms: A Randomized Controlled Clinical Trial
Asiaticoside 📋 35707715Computation-Based Discovery of Potential Targets for Rheumatoid Arthritis and Related Molecular Screening and Mechanism Analysis of Traditional Chinese Medicine
Aspirin 📋 ⛔34384858The effect of association of aspirin and omega 3 in rat temporomandibular joint with induced arthritis
Astragalin 📋 30809149Astragalin Suppresses Inflammatory Responses and Bone Destruction in Mice With Collagen-Induced Arthritis and in Human Fibroblast-Like Synoviocytes
Atractylodes 📋✍⛔35658881The Anti-hyperuricemia and Anti-inflammatory Effects of Atractylodes Macrocephala in Hyperuricemia and Gouty Arthritis Rat Models
Barberry 📋✍⛔35254584Berberis lycium fruit extract and its phytoconstituents berberine and rutin mitigate collagen-CFA-induced arthritis (CIA) via improving GSK3β/STAT/Akt/MAPKs/NF-κB signaling axis mediated oxi-inflammation and joint articular damage in murine model
Beta-Carotene 📋✍⛔35145506Effects of β-Carotin and Green Tea Powder Diets on Alleviating the Symptoms of Gouty Arthritis and Improving Gut Microbiota in C57BL/6 Mice
Beta-Sitosterol 📋✍⛔35295740β-Sitosterol Inhibits Rheumatoid Synovial Angiogenesis Through Suppressing VEGF Signaling Pathway
Biochanin A 📋 36379122Biochanin A protects against iron overload associated knee osteoarthritis via regulating iron levels and NRF2/System xc-/GPX4 axis
Black Pepper 📋✍⛔33362443Treatment of Psoriatic Arthritis With Acupuncture, Turmeric ( Curcuma longa), Sarsaparilla ( Smilax officinalis) and Vitamin D: A Case Report
Blackcurrant 📋✍⛔30771518Amelioration of adjuvant induced arthritis in Sprague Dawley rats through modulation of inflammatory mediators by Ribes alpestre Decne
Burdock 📋 ⛔28801728Arctium minus crude extract presents antinociceptive effect in a mice acute gout attack model
Carnosol 📋 37415927Carnosol Alleviates Collagen-Induced Arthritis by Inhibiting Th17-Mediated Immunity and Favoring Suppressive Activity of Regulatory T Cells
Chlorogenic Acid 📋✍⛔36355499Chlorogenic Acid Relieves the Lupus Erythematosus-like Skin Lesions and Arthritis in MRL/lpr Mice
Cordyceps 📋✍⛔36313318Transcriptomic analysis of the anti-inflammatory effect of Cordyceps militaris extract on acute gouty arthritis
Cornus 📋 33897428Combined Cornus Officinalis and Paeonia Lactiflora Pall Therapy Alleviates Rheumatoid Arthritis by Regulating Synovial Apoptosis via AMPK-Mediated Mitochondrial Fission
Cranberry 📋✍⛔33636418Beneficial effects of fish oil and cranberry juice on disease activity and inflammatory biomarkers in people with rheumatoid arthritis
Cryptotanshinone 📋 36147634Radix Salvia miltiorrhiza for Ankylosing Spondylitis: Determining Potential Inflammatory Molecular Targets and Mechanism Using Network Pharmacology
Cucumber 📋 ⛔36748212Standardised ido-BR1 Cucumber Extract Improved Parameters Linked to Moderate Osteoarthritis in a Placebo-controlled Study
Cyanidin 📋✍ 34863656Cyanidin restores Th17/Treg balance and inhibits T follicular helper cell differentiation via modulation of ROCK2 signaling in an experimental model of rheumatoid arthritis
Daidzein 📋✍⛔34630655Effects of isoflavone derivatives on the production of inflammatory cytokines by synovial cells
Dihydroartemisinin 📋 38447418Dihydroartemisinin alleviates erosive bone destruction by modifying local Treg cells in inflamed joints: A novel role in the treatment of rheumatoid arthritis
Diosgenin 📋 37188832Diosgenin, a steroidal sapogenin, arrests arthritis through modulation of inflammatory cytokines and oxidative stress biomarkers in Wistar rats
Eicosapentaenoic Acid 📋✍⛔38339087Beneficial Impact of Eicosapentaenoic Acid on the Adverse Effects Induced by Palmitate and Hyperglycemia on Healthy Rat Chondrocyte
Emu Oil 📋✍⛔27178879Amelioration of FCA induced arthritis on topical application of curcumin in combination with emu oil
Fenugreek 📋✍⛔37039783Effects of Trigonella foenum graecum (Fenugreek) on Rheumatoid Arthritis: A Systematic Review
Ferulic Acid 📋✍⛔34529586Ferulic acid attenuates osteoporosis induced by glucocorticoid through regulating the GSK-3β/Lrp-5/ERK signalling pathways
Fiber 📋✍⛔38287064Associations of cereal fiber intake with rheumatoid arthritis mediated by dietary inflammatory index: insights from NHANES 2011-2020
Fisetin 📋✍⛔38278314Fisetin suppresses chondrocyte senescence and attenuates osteoarthritis progression by targeting sirtuin 6
Fish 📋 ⛔35907830The relationship between animal flesh foods consumption and rheumatoid arthritis: a case-control study
Formononetin 📋 36306560Formononetin inhibits IL-1β-induced inflammation in human chondrocytes and slows the progression of osteoarthritis in rat model via the regulation of PTEN/AKT/NF-κB pathway
Fruits 📋 38672942Dietary Factors and Risk of Gout: A Two-Sample Mendelian Randomization Study
Galangal 📋✍⛔33818795Chondroprotective effect of Alpinia oxyphylla extract in experimentally induced cartilage degradation in rabbit articular cartilage explants
Ganoderic Acid 📋 37984927Ganoderic acid A slows osteoarthritis progression by attenuating endoplasmic reticulum stress and blocking NF-Κb pathway
Gardenia 📋 ⛔37474993[Mechanism of Gardeniae Fructus in ameliorating rheumatoid arthritis based on metabolomics and intestinal microbiota]
Geraniol 📋 37841186Geraniol Suppresses Oxidative Stress, Inflammation, and Interstitial Collagenase to Protect against Inflammatory Arthritis
Gingerol 📋✍ 27463229Elucidating the Role of Protandim and 6-Gingerol in Protection Against Osteoarthritis
Guava 📋 ⛔35818211The effect of Psidium guajava hydroalcoholic extract on reducing the expression of Resistin and TNF-α genes in articular chondrocytes of patients with knee osteoarthritis
Hesperetin 📋 32159191The protective effect of hesperetin in osteoarthritis: an in vitro and in vivo study
Honey 📋✍⛔36453014A randomized, double-blind placebo-controlled phase I clinical study on safety and efficacy of the G-Rup® syrup (a mixture of ginger extract and honey) in symptomatic treatment of knee osteoarthritis
Irisin 📋 38154212Irisin mitigates rheumatoid arthritis by suppressing mitochondrial fission via inhibiting YAP-Drp1 signaling pathway
Jasmine 📋 ⛔34119929Anti-inflammatory activity of Jasminum grandiflorum L. subsp. floribundum (Oleaceae) in inflammatory bowel disease and arthritis models
L-Arginine 📋✍⛔37775153L-arginine metabolism inhibits arthritis and inflammatory bone loss
Ligustilide 📋 30770640Ligustilide attenuates nitric oxide-induced apoptosis in rat chondrocytes and cartilage degradation via inhibiting JNK and p38 MAPK pathways
Linalool 📋 ⛔37348232Linalool: Monoterpene alcohol effectiveness in chronic synovitis through lowering Interleukin-17, spleen and thymus indices
Lipoic Acid 📋✍⛔31602508Administration of Alpha-Lipoic Acid Could Maintain Bone Mass and Bone Strength in Senile Female Rats With Alcohol Consumption
Liquiritigenin 📋 37005251Liquiritigenin Attenuated Collagen-Induced Arthritis and Cardiac Complication via Inflammation and Fibrosis Inhibition in Mice
Liquiritin 📋 38423170Liquiritin reduces chondrocyte apoptosis through P53/PUMA signaling pathway to alleviate osteoarthritis
Long Pepper 📋 ⛔38670409Piper longum L. ameliorates gout through the MAPK/PI3K-AKT pathway
Madecassoside 📋 33039960Regulation of gut microbiota substantially contributes to the induction of intestinal Treg cells and consequent anti-arthritis effect of madecassoside
Mango Leaf 📋 ⛔26229343Antiarthritic activity of a polyherbal formulation against Freund's complete adjuvant induced arthritis in Female Wistar rats
Moringa Oleifera 📋✍⛔29629295In vivo anti-arthritic and anti-nociceptive effects of ethanol extract of Moringa oleifera leaves on complete Freund's adjuvant (CFA)-induced arthritis in rats
Myricetin 📋 ⛔38164247Selective blockade of IL-21 by myricetin impedes T follicular helper cell differentiation by negatively regulating the JAK/STAT/Bcl-6 pathway in a rheumatoid arthritis animal model
Nicotinamide Riboside 📋✍⛔37959383The Potential Benefic Effect of Nicotinamide Riboside in Treating a Murine Model of Monoiodoacetate-Induced Knee Osteoarthritis
Olive Oil 📋✍⛔36839323Olive Oil and Nuts in Rheumatoid Arthritis Disease Activity
Paeonol 📋 35235465Paeonol inhibits inflammatory response and protects chondrocytes by upregulating sirtuin 1
Phytoestrogens 📋 ⛔33254019A mechanistic insight of phytoestrogens used for Rheumatoid arthritis: An evidence-based review
Piperine 📋✍⛔37536000Piperine suppresses inflammatory fibroblast-like synoviocytes derived from rheumatoid arthritis patients Via NF-κB inhibition
Piperlongumine 📋 38334976Protective effects of piperlongumine against adjuvant-induced arthritis in rats through modulating OPG/RANKL/NF-κB signaling pathway
Plum 📋 ⛔36673346Anti-Inflammatory Effects of Polyphenols from Plum ( Prunus salicina Lindl) on RAW264.7 Macrophages Induced by Monosodium Urate and Potential Mechanisms
PQQ 📋✍⛔33582913Protective Effect of Pyrroloquinoline Quinone on TNF-α-induced Mitochondrial Injury in Chondrocytes
Prebiotics 📋✍⛔37077156Prebiotics alleviate cartilage degradation and inflammation in post-traumatic osteoarthritic mice by modulating the gut barrier and fecal metabolomics
Prunella Vulgaris 📋✍⛔36670908Anti-Osteoarthritic Effects of Prunella Vulgaris and Gentiana Lutea In Vitro and In Vivo
Quercitrin 📋 37952573Quercitrin attenuates the progression of osteoarthritis via inhibiting NF-κB signaling pathways and enhance glucose transport capacity
Retinoic Acid 📋 38245637All-trans retinoic acid alleviates collagen-induced arthritis and promotes intestinal homeostasis
Rhodiola 📋✍⛔38156377Mechanism of Rhodiola rosea-Euonymus alatus drug pair against rheumatoid arthritis: Network pharmacology and experimental validation
Safranal 📋 35899925Safranal Treatment Induces Sirt1 Expression and Inhibits Endoplasmic Reticulum Stress in Mouse Chondrocytes and Alleviates Osteoarthritis Progression in a Mouse Model
Scutellarein 📋 38695125Scutellarein alleviates osteoarthritis progression through the PI3K/Akt/NF-kappaB signaling pathway: In vitro and in vivo studies
Sesame 📋✍⛔35733624A Randomized Controlled Trial of Thai Medicinal Plant-4 Cream versus Diclofenac Gel in the Management of Symptomatic Osteoarthritis of the Knee
Sesamin 📋✍ 38002386Anti-COVID-19, Anti-Inflammatory, and Anti-Osteoarthritis Activities of Sesamin from Sesamum indicum L
Shea 📋 ⛔32099450Vitellaria paradoxa Nut Triterpene-Rich Extract Ameliorates Symptoms of Inflammation on Post-Traumatic Osteoarthritis in Obese Rats
Spikenard 📋✍⛔35962465Nardosinone suppresses monoiodoacetate-induced osteoarthritis in rats: The key role of the miR-218-5p/NUMB axis
Spirulina 📋✍⛔30687122Selenium-Containing Protein From Selenium-Enriched Spirulina platensis Attenuates Cisplatin-Induced Apoptosis in MC3T3-E1 Mouse Preosteoblast by Inhibiting Mitochondrial Dysfunction and ROS-Mediated Oxidative Damage
Stevia 📋✍⛔36630751Stevioside targets the NF-κB and MAPK pathways for inhibiting inflammation and apoptosis of chondrocytes and ameliorates osteoarthritis in vivo
Stinging Nettle 📋✍⛔20015358Phytalgic, a food supplement, vs placebo in patients with osteoarthritis of the knee or hip: a randomised double-blind placebo-controlled clinical trial
Syringic Acid 📋 38616762Syringic Acid Attenuates the IL-1β-Induced Akt Pathway in Chondrocyte ATDC5 Cells
Vitamin B9 📋✍⛔38329818The association of folate deficiency with clinical and radiological severity of knee osteoarthritis
Vitamin K2 📋✍⛔33040843Suppressive effect of vitamin K2 against mitogen-activated peripheral blood mononuclear cells of rheumatoid arthritis patients
Vitamin K2 mk-4 📋✍ 18484089Vitamin K and rheumatoid arthritis
Withaferin A 📋 38345447Withaferin A alleviates inflammation and joint injury in arthritic rats via elevating microRNA-1297 to target karyopherin alpha2
Wormwood 📋✍⛔36335258Systems pharmacology approach to investigate the mechanism of Artemisia argyi in treating rheumatic diseases
Zingerone 📋 33784959Zingerone (4-(four-hydroxy-3-methylphenyl) butane-two-1) modulates adjuvant-induced rheumatoid arthritis by regulating inflammatory cytokines and antioxidants
5-HTP 📋✍⛔26669765Supplement of 5-hydroxytryptophan before induction suppresses inflammation and collagen-induced arthritis
Aloe-Emodin 📋 28487948Effect of aloe‑emodin on the proliferation and apoptosis of human synovial MH7A cells; a comparison with methotrexate
Aloin 📋 33096361Inhibition of PI3K/Akt/NF-κB signaling by Aloin for ameliorating the progression of osteoarthritis: In vitro and in vivo studies
Alpha GPC 📋✍⛔29191088The delaying effect of alpha-glycerophosphocholine on senescence, transthyretin deposition, and osteoarthritis in senescence-accelerated mouse prone 8 mice
Amaranth 📋 ⛔32529499Dietary amaranths modulate the immune response via balancing Th1/Th2 and Th17/Treg response in collagen-induced arthritis
Amygdalin 📋✍⛔37894605TMT-Based Proteomics Reveal the Mechanism of Action of Amygdalin against Rheumatoid Arthritis in a Rat Model through Regulation of Complement and Coagulation Cascades
Arjuna 📋✍⛔25294686Amelioration of oxidative stress in the joint tissue may be the basis for the antiarthritic activity of Terminalia arjuna bark extract
Arnica 📋✍⛔25966322Cumulative therapeutic effects of phytochemicals in Arnica montana flower extract alleviated collagen-induced arthritis: inhibition of both pro-inflammatory mediators and oxidative stress
Balloon Flower 📋✍⛔37138547Platycodin D relieves rheumatoid arthritis by promoting apoptosis of mitochondria to inhibit activation of hedgehog pathway
Bergamot 📋✍⛔37748407Bergapten exerts a chondroprotective effect in temporomandibular joint osteoarthritis by combining intestinal flora alteration and reactive oxygen species reduction
Betaine 📋✍⛔34658862Betaine Attenuates Osteoarthritis by Inhibiting Osteoclastogenesis and Angiogenesis in Subchondral Bone
Betulinic Acid 📋 37789884Betulinic Acid Attenuates Osteoarthritis via Limiting NLRP3 Inflammasome Activation to Decrease Interleukin-1 β Maturation and Secretion
Bilobalide 📋 36337189Natural product, bilobalide, improves joint health in rabbits with osteoarthritis by anti-matrix degradation and antioxidant activities
Black Ginger 📋✍⛔33799537Kaempferia parviflora Extract Alleviated Rat Arthritis, Exerted Chondroprotective Properties In Vitro, and Reduced Expression of Genes Associated with Inflammatory Arthritis
Boric Acid 📋✍⛔37770671Anti-Inflammatory Effects of Boric Acid in Treating Knee Osteoarthritis: Biochemical and Histopathological Evaluation in Rat Model
Boron 📋✍⛔7889887Essentiality of Boron for Healthy Bones and Joints
Bread 📋 36130461Whole grain consumption and risk of radiographic knee osteoarthritis: a prospective study from the Osteoarthritis Initiative
Broccoli 📋 ⛔34704882Bioactive compounds and therapeutic role of Brassica oleracea L. seeds in rheumatoid arthritis rats via regulating inflammatory signaling pathways and antagonizing interleukin-1 receptor action
Buckwheat 📋 ⛔23675837Anti-arthritic activity of ethanol extract of Fagopyrum cymosum with adjuvant-induced arthritis in rats
Butyrate 📋 ⛔36325344Lactobacillus (LA-1) and butyrate inhibit osteoarthritis by controlling autophagy and inflammatory cell death of chondrocytes
Cabbage 📋 ⛔35719197Efficacy of Cabbage Leaf versus Cooling Gel Pad or Diclofenac Gel for Patients with Knee Osteoarthritis: A Randomized Open-Labeled Controlled Clinical Trial
Caffeic Acid 📋✍⛔30562713Caffeic acid and ellagic acid ameliorate adjuvant-induced arthritis in rats via targeting inflammatory signals, chitinase-3-like protein-1 and angiogenesis
Camphor 📋✍⛔20353012[Study on antiinflammatory effect of different chemotype of Cinnamomum camphora on rat arthritis model induced by Freund's adjuvant]
CAPE 📋 36102306Caffeic acid phenethyl ester attenuates osteoarthritis progression by activating NRF2/HO‑1 and inhibiting the NF‑κB signaling pathway
Castor Oil 📋✍⛔34712426Anti-arthritic activity of Ricinus communis L. and Withania somnifera L. extracts in adjuvant-induced arthritic rats via modulating inflammatory mediators and subsiding oxidative stress
Catalase 📋✍⛔37879214Combination of curcumin and catalase protects against chondrocyte injury and knee osteoarthritis progression by suppressing oxidative stress
Chamomile Essential Oil 📋✍⛔32334386α-Bisabolol suppresses the inflammatory response and ECM catabolism in advanced glycation end products-treated chondrocytes and attenuates murine osteoarthritis
Cheese 📋 ⛔38672942Dietary Factors and Risk of Gout: A Two-Sample Mendelian Randomization Study
Chicoric Acid 📋 35961266Chicoric acid attenuates tumor necrosis factor-α-induced inflammation and apoptosis via the Nrf2/HO-1, PI3K/AKT and NF-κB signaling pathways in C28/I2 cells and ameliorates the progression of osteoarthritis in a rat model
Chitosan 📋✍⛔33291821Chitosan and Lecithin Ameliorate Osteoarthritis Symptoms Induced by Monoiodoacetate in a Rat Model
Cinnamic Acid 📋 35799788A Novel Drug Combination of Mangiferin and Cinnamic Acid Alleviates Rheumatoid Arthritis by Inhibiting TLR4/NFκB/NLRP3 Activation-Induced Pyroptosis
Citronella Essential Oil 📋✍⛔38498112Potential anti-gouty arthritis of Citronella essential oil and Nutmeg essential oil through reducing oxidative stress and inhibiting PI3K/Akt/mTOR activation-induced NLRP3 activity
Clary Sage Essential Oil 📋✍⛔26045743Sclareol exerts anti-osteoarthritic activities in interleukin-1β-induced rabbit chondrocytes and a rabbit osteoarthritis model
Conjugated Linoleic Acid 📋✍⛔20374312Effect of Conjugated Linoleic Acids, Vitamin E and Their Combination on the Clinical Outcome of Iranian Adults With Active Rheumatoid Arthritis
Copper 📋✍⛔37875826Association between magnesium, copper, and potassium intakes with risk of rheumatoid arthritis: a cross-sectional study from National Health and Nutrition Examination Survey (NHANES)
Coptis Chinensis 📋 ⛔37637408Therapeutic potential of Coptis chinensis for arthritis with underlying mechanisms
Coriander 📋 ⛔34836295Ameliorating Effects of Coriander on Gastrocnemius Muscles Undergoing Precachexia in a Rat Model of Rheumatoid Arthritis: A Proteomics Analysis
Corn 📋 ⛔33479339Chondroprotective effects of purple corn anthocyanins on advanced glycation end products induction through suppression of NF-κB and MAPK signaling
Corn Silk 📋✍⛔36276864Treatment of Gout with TCM Using Turmeric and Corn Silk: A Concise Review Article and Pharmacology Network Analysis
Crocetin 📋 30618728In vivo and in vitro Approach to Anti-arthritic and Anti-inflammatory Effect of Crocetin by Alteration of Nuclear Factor-E2-Related Factor 2/hem Oxygenase (HO)-1 and NF-κB Expression
D-Mannose 📋✍⛔34561933D-mannose alleviates osteoarthritis progression by inhibiting chondrocyte ferroptosis in a HIF-2α-dependent manner
Delphinidin 📋 34825313Delphinidin diminishes in vitro interferon-γ and interleukin-17 producing cells in patients with psoriatic disease
DHEA 📋✍⛔23085002The chondroprotective effects of dehydroepiandrosterone probably exerted by its conversion to estradiol
Diallyl Trisulfide 📋 30897500Diallyl Trisulfide can induce fibroblast-like synovial apoptosis and has a therapeutic effect on collagen-induced arthritis in mice via blocking NF-κB and Wnt pathways
DIM 📋✍⛔364388023,3'-diindolylmethane inhibits LPS-induced human chondrocytes apoptosis and extracellular matrix degradation by activating PI3K-Akt-mTOR-mediated autophagy
Diosmetin 📋 36563736Diosmetin inhibits subchondral bone loss and indirectly protects cartilage in a surgically-induced osteoarthritis mouse model
Echinacea 📋✍⛔27737573The Effect and Safety of Highly Standardized Ginger (Zingiber Officinale) and Echinacea (Echinacea Angustifolia) Extract Supplementation on Inflammation and Chronic Pain in NSAIDs Poor Responders. A Pilot Study in Subjects With Knee Arthrosis
Equol 📋✍⛔36311191Protective effects of equol on the cartilage and subchondral bone in ovariectomized rats with osteoarthritis
Eucalyptus 📋✍⛔36060153The effect of eucalyptus inhalation on pain and the quality of life in rheumatoid arthritis
Fennel 📋✍⛔32835919Effect of sweet fennel seed extract capsule on knee pain in women with knee osteoarthritis
Flaxseed 📋✍⛔34837524The effect of flaxseed with or without anti-inflammatory diet in patients with rheumatoid arthritis, a randomized controlled trial
Flaxseed Oil 📋✍⛔35099432Efficacy of Flaxseed and Fish Oils on Adults with Rheumatoid Arthritis
Fucoxanthin 📋✍⛔33673704Fucoxanthin Suppresses Osteoclastogenesis via Modulation of MAP Kinase and Nrf2 Signaling
Gamma-Linolenic Acid 📋✍⛔19941324Evidence of effectiveness of herbal medicinal products in the treatment of arthritis. Part 2: Rheumatoid arthritis
Genipin 📋 33103838Effects of short-duration treatment of cartilage with punicalagin and genipin and the implications for treatment of osteoarthritis
Geranium 📋 35832768Geranium wallichianum D. Don Ex Sweet Ameliorates Rheumatoid Arthritis by Curtailing the Expression of COX-II and Inflammatory Cytokines as Well as by Alleviating the Oxidative Stress
Giloy 📋✍⛔36840884In vitro and in vivo anti-inflammatory and anti-arthritic effect of Tinospora cordifolia via modulation of JAK/STAT pathway
Glabridin 📋 33417956Glabridin inhibits osteoarthritis development by protecting chondrocytes against oxidative stress, apoptosis and promoting mTOR mediated autophagy
Glutathione 📋✍⛔33717929The protective role of glutathione in osteoarthritis
Grape Seed Oil 📋 ⛔32912277The protective effects of grape seed oil on induced osteoarthritis of the knee in male rat models
Grapefruit 📋 ⛔36839155Chondroprotective Effects of Grapefruit ( Citrus paradisi Macfad.) Juice in a Complete Freund's Adjuvant Rat Model of Knee Osteoarthritis
Grapefruit Essential Oil 📋✍⛔35583855Chemical constituents, biological activities and anti-rheumatoid arthritic properties of four citrus essential oils
Guggul 📋✍⛔27548493Effects of Balsamodendron mukul Gum Resin Extract on Articular Cartilage in Papain-induced Osteoarthritis
Hemp Oil 📋✍⛔36837393Hemp Seed Oil in Association with β-Caryophyllene, Myrcene and Ginger Extract as a Nutraceutical Integration in Knee Osteoarthritis: A Double-Blind Prospective Case-Control Study
HMB 📋✍⛔15896432Dietary Treatment of Rheumatoid Cachexia With Beta-Hydroxy-Beta-Methylbutyrate, Glutamine and Arginine: A Randomised Controlled Trial
Hyperoside 📋 33130473Hyperoside ameliorates the progression of osteoarthritis: An in vitro and in vivo study
Indian Mulberry 📋✍⛔38403321[UPLC-Q-TOF-MS-based metabolomics reveals mechanism of Morinda officinalis iridoid glycosides in treating rheumatoid arthritis and bone loss]
Isoquercitrin 📋 38065271Isoquercitrin attenuates the osteoclast-mediated bone loss in rheumatoid arthritis via the Nrf2/ROS/NF-κB pathway
Isorhamnetin 📋 38212502Isorhamnetin Downregulates MMP2 and MMP9 to Inhibit Development of Rheumatoid Arthritis through SRC/ERK/CREB Pathway
Jujube 📋 ⛔36896317Effects of Ziziphus Jujuba Extract Alone and Combined with Boswellia Serrata Extract on Monosodium Iodoacetate Model of Osteoarthritis in Mice
Kudzu Root 📋✍⛔29121799Pueraria lobate Inhibits RANKL-Mediated Osteoclastogenesis Via Downregulation of CREB/PGC1β/c-Fos/NFATc1 Signaling
L-Carnosine 📋✍⛔35740105Carnosine Alleviates Knee Osteoarthritis and Promotes Synoviocyte Protection via Activating the Nrf2/HO-1 Signaling Pathway: An In-Vivo and In-Vitro Study
L-Theanine 📋✍⛔32635404L-Theanine Reduced the Development of Knee Osteoarthritis in Rats via Its Anti-Inflammation and Anti-Matrix Degradation Actions: In Vivo and In Vitro Study
L-Tryptophan 📋✍⛔12966593Increased degradation of tryptophan in blood of patients with rheumatoid arthritis
Lactobacillus plantarum 📋 ⛔28685302Anti-arthritic activity of cell wall content of Lactobacillus plantarum in freund's adjuvant-induced arthritic rats: involvement of cellular inflammatory mediators and other biomarkers
Lauric Acid 📋✍ 33359913Fatty acid sensing GPCR (GPR84) signaling safeguards cartilage homeostasis and protects against osteoarthritis
Lavender Essential Oil 📋✍⛔27863613Effect of aromatherapy massage with lavender essential oil on pain in patients with osteoarthritis of the knee: A randomized controlled clinical trial
Lecithin 📋✍⛔33291821Chitosan and Lecithin Ameliorate Osteoarthritis Symptoms Induced by Monoiodoacetate in a Rat Model
Lemon Essential Oil 📋✍⛔35583855Chemical constituents, biological activities and anti-rheumatoid arthritic properties of four citrus essential oils
Lemon Verbena 📋 ⛔22087615A randomized, double-blinded, placebo-controlled study of the effect of a combination of lemon verbena extract and fish oil omega-3 fatty acid on joint management
Limonin 📋 34795843Limonin Inhibits IL-1 β-Induced Inflammation and Catabolism in Chondrocytes and Ameliorates Osteoarthritis by Activating Nrf2
Lion's Mane Mushrooms 📋✍⛔35807786Hericium erinaceus Mycelium Ameliorates In Vivo Progression of Osteoarthritis
Loquat 📋✍⛔31770567Anti-inflammatory and anti-arthritic activity in extract from the leaves of Eriobotrya japonica
Lotus 📋 ⛔37028495Study on the anti-gout activity of the lotus seed pod by UPLC-QTOF-MS and virtual molecular docking
Lupeol 📋 35446470Protective effect of lupeol on arthritis induced by type II collagen via the suppression of P13K/AKT signaling pathway in Sprague dawley rats
Magnolia 📋✍⛔33990219Fargesin ameliorates osteoarthritis via macrophage reprogramming by downregulating MAPK and NF-κB pathways
Mango 📋 ⛔35662629Anti-inflammatory and immunomodulatory activity of Mangifera indica L. reveals the modulation of COX-2/mPGES-1 axis and Th17/Treg ratio
Mastic 📋✍⛔34378260Effectiveness of Pistacia atlantica on older adult knee osteoarthritis, a randomized triple blind clinical trial
Minerals 📋 35004740The Impact of Trace Elements on Osteoarthritis
Modified Citrus Pectin 📋✍⛔25689620Galectin-3 is a sensor-regulator of toll-like receptor pathways in synovial fibroblasts
Morin 📋 36121554Morin, the PPARγ agonist, inhibits Th17 differentiation by limiting fatty acid synthesis in collagen-induced arthritis
Morusin 📋 32273685Morusin Ameliorates IL-1β-Induced Chondrocyte Inflammation and Osteoarthritis via NF-κB Signal Pathway
Myrrh 📋✍⛔31908521Effect Of E-OA-07 On Improving Joint Health And Mobility In Individuals With Knee Osteoarthritis: A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study
Neohesperidin 📋 34688464Therapeutic effect of neohesperidin on TNF-α-stimulated human rheumatoid arthritis fibroblast-like synoviocytes
Nicotinamide 📋✍⛔34282229Niacinamide and undenatured type II collagen modulates the inflammatory response in rats with monoiodoacetate-induced osteoarthritis
NMN 📋✍⛔37094367Preclinical characterization of pharmacological NAD+ boosting as a promising therapeutic approach in Rheumatoid Arthritis
Noni 📋 ⛔34359507MicroRNAs Involved in the Therapeutic Functions of Noni ( Morinda citrifolia L.) Fruit Juice in the Treatment of Acute Gouty Arthritis in Mice Induced with Monosodium Urate
Nootkatone 📋 34492535Nootkatone protects cartilage against degeneration in mice by inhibiting NF-κB signaling pathway
Nuciferine 📋 38658097Nuciferine alleviates collagen-induced arthritic in rats by inhibiting the proliferation and invasion of human arthritis-derived fibroblast-like synoviocytes and rectifying Th17/Treg imbalance
Nutmeg Essential Oil 📋 ⛔38498112Potential anti-gouty arthritis of Citronella essential oil and Nutmeg essential oil through reducing oxidative stress and inhibiting PI3K/Akt/mTOR activation-induced NLRP3 activity
Nuts 📋 ⛔36839323Olive Oil and Nuts in Rheumatoid Arthritis Disease Activity
Oleanolic Acid 📋 37856220Oleanolic acid, a small-molecule natural product, inhibits ECM degeneration in osteoarthritis by regulating the Hippo/YAP and Wnt/β-catenin pathways
Orange 📋 ⛔20707201[Effect and mechanism of total flavonoids of orange peel on rat adjuvant arthritis]
Orange Essential Oil 📋✍⛔35583855Chemical constituents, biological activities and anti-rheumatoid arthritic properties of four citrus essential oils
Papain 📋✍⛔32122870Efficiency of proteolytic enzymes in treating lumbar spine osteoarthritis (low back pain) patients and its effects on liver and kidney enzymes
Patchouli 📋✍⛔35720186Patchouli Alcohol Inhibits D-Gal Induced Oxidative Stress and Ameliorates the Quality of Aging Cartilage via Activating the Nrf2/HO-1 Pathway in Mice
Pau d'Arco 📋✍⛔29317792Tabetri™ ( Tabebuia avellanedae Ethanol Extract) Ameliorates Osteoarthritis Symptoms Induced by Monoiodoacetate through Its Anti-Inflammatory and Chondroprotective Activities
PEA 📋✍⛔34468900Anti-inflammatory activity of palmitoylethanolamide ameliorates osteoarthritis induced by monosodium iodoacetate in Sprague-Dawley rats
Pelargonidin 📋 37315775Pelargonidin ameliorates inflammatory response and cartilage degeneration in osteoarthritis via suppressing the NF-κB pathway
Perilla 📋✍ 36413851A methoxyflavanone from the medicinal herb Perilla frutescens down-modulates Th17 response and ameliorates collagen-induced arthritis
Persimmon 📋 ⛔31359802Anti-inflammatory Effects of Persimmon ( Diospyros kaki L.) in Experimental Rodent Rheumatoid Arthritis
Phosphatidylcholine 📋✍⛔21194249Efficacy and Safety of Meriva®, a Curcumin-Phosphatidylcholine Complex, During Extended Administration in Osteoarthritis Patients
Pine Nut 📋 ⛔34080609Anti-inflammatory and immunoregulatory effects of pinolenic acid in rheumatoid arthritis
Pineapple 📋✍⛔27181794Anti-rheumatic activity of Ananas comosus fruit peel extract in a complete Freund's adjuvant rat model
Potassium 📋✍⛔37875826Association between magnesium, copper, and potassium intakes with risk of rheumatoid arthritis: a cross-sectional study from National Health and Nutrition Examination Survey (NHANES)
Raspberry 📋✍⛔35799169Rubus idaeus extract improves symptoms in knee osteoarthritis patients: results from a phase II double-blind randomized controlled trial
Rehmannia 📋✍⛔37674829Rehmannia alcohol extract inhibits neuropeptide secretion and alleviates osteoarthritis pain through cartilage protection
Rosemary Essential Oil 📋✍⛔31144450Effects of aromatherapy massage on pain, functional state, and quality of life in an elderly individual with knee osteoarthritis
Rosmarinic Acid 📋✍ 25058311High-rosmarinic acid spearmint tea in the management of knee osteoarthritis symptoms
Royal Jelly 📋✍⛔36724964Amelioration of Osteoarthritis Development by Daily Oral Supplementation of Royal Jelly
Salvianolic Acid 📋 35922815Salvianolic acid B activates chondrocytes autophagy and reduces chondrocyte apoptosis in obese mice via the KCNQ1OT1/miR-128-3p/SIRT1 signaling pathways
Seafood 📋 35907830The relationship between animal flesh foods consumption and rheumatoid arthritis: a case-control study
Sesame Oil 📋 ⛔31780006The efficacy of topical sesame oil in patients with knee osteoarthritis: A randomized double-blinded active-controlled non-inferiority clinical trial
Sesamol 📋 37778247Sesamol serves as a p53 stabilizer to relieve rheumatoid arthritis progression and inhibits the growth of synovial organoids
Shiitake Mushrooms 📋✍⛔21106932White button and shiitake mushrooms reduce the incidence and severity of collagen-induced arthritis in dilute brown non-agouti mice
Spearmint 📋 ⛔25058311High-rosmarinic acid spearmint tea in the management of knee osteoarthritis symptoms
Spearmint Essential Oil 📋✍⛔28107842Mentha spicata as natural analgesia for treatment of pain in osteoarthritis patients
Spices 📋 33322318Efficacy of Spice Supplementation in Rheumatoid Arthritis: A Systematic Literature Review
St. Johns Wort 📋✍⛔33063931Astilbin prevents osteoarthritis development through the TLR4/MD-2 pathway
St. Johns Wort Oil 📋 ⛔38242739The Effect of St. John's Wort Oil (Hypericum Perforatum L.) in Knee Osteoarthritis: A Randomized Controlled and Qualitative Study
Sweet Potato 📋 ⛔37953101Purple sweet potato (Ipomoea batatas L.) extract effects on levels of inflammatory markers and chondrocyte count in gout arthritis Wistar rat model
Telmisartan 📋 ⛔34056329Telmisartan Mitigates TNF-α-Induced Type II Collagen Reduction by Upregulating SOX-9
Terpenoids 📋 35368757Activities and Molecular Mechanisms of Diterpenes, Diterpenoids, and Their Derivatives in Rheumatoid Arthritis
Tetrahydrocurcumin 📋✍ 27482294Curcumin and Tetrahydrocurcumin Both Prevent Osteoarthritis Symptoms and Decrease the Expressions of Pro-Inflammatory Cytokines in Estrogen-Deficient Rats
Theobromine 📋✍⛔32146317Theobromine mitigates IL-1β-induced oxidative stress, inflammatory response, and degradation of type II collagen in human chondrocytes
Thyme 📋✍⛔31124455Comparative study of the effect of Thymus daenensis gel 5% and diclofenac in patients with knee osteoarthritis
Toothache Plant 📋 32368129The Use of a New Food-Grade Lecithin Formulation of Highly Standardized Ginger ( Zingiber officinale) and Acmella oleracea Extracts for the Treatment of Pain and Inflammation in a Group of Subjects With Moderate Knee Osteoarthritis
Trehalose 📋 ⛔37622696Anti-arthritic and antioxidant effects of trehalose in an experimental model of arthritis
Tribulus Terrestris 📋✍⛔28849084Effects of Tribulus terrestris on monosodium iodoacetate‑induced osteoarthritis pain in rats
UDCA 📋✍⛔38313166Evaluating the effect of ursodeoxycholic acid (UDCA) in comparison with dexamethasone and diclofenac in a rat model of rheumatoid arthritis
Vitamin B3 📋✍⛔38180674Association between niacin intake and knee osteoarthritis pain and function: a longitudinal cohort study
Vitamin K2 mk-7 📋✍ 26073022Menaquinone-7 as a Novel Pharmacological Therapy in the Treatment of Rheumatoid Arthritis: A Clinical Study
Vitex 📋✍⛔36121091Potential Phytoconstituents of Genus Vitex for the Management of Rheumatoid Arthritis: A Review
Vitexin 📋 36029189Vitexin alleviates inflammation and enhances apoptosis through the regulation of the JAK/STAT/SOCS signaling pathway in the arthritis rat model
Withanolides 📋 34925020Physalin A Inhibits MAPK and NF-κB Signal Transduction Through Integrin αVβ3 and Exerts Chondroprotective Effect
Yam 📋 34721647Total Saponin of Dioscorea collettii Attenuates MSU Crystal-Induced Inflammation by Inhibiting the Activation of the TLR4/NF- κ B Signaling Pathway